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Furthermore, glutamine-derived fumarate, malate, and citrate are significantly increased when glucose is deprived, demonstrating that glutamine drives the glucose-independent TCA cycle in a nutrient-poor tumor microenvironment (Le et al., 2012)
The SCFAs were shown their treatment had antidepressant benefits by reducing the permeability and the HPA axis, particularly butyrate (168, 169)
Targeting VEGF due to its over-secretion during tumor progression has also prompted the use of bevacizumab, an anti-human VEGF monoclonal antibody that reduces the growth of tumor vessels [33, 34]